Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery.

Of the more than 190 different species of the genus Mycobacterium, many of which are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species are Mycobacterium tuberculosis (the agent causing tuberculosis), Mycobacterium leprae (leprosy-causing agents) and Mycobacterium abscessus (agents causing chronic lung infections) pose a concern for global public health.

Although antibiotics have been developed to combat each, the emergence of drug-resistant strains is an increasing challenge for medicine and drug discovery. Here we describe the impact of the rapid expansion of genome sequencing and genome / explanation which has greatly improved track progress structure-guided drug discovery.

We focus on the application of comparative genomics, metabolomics, bioinformatics evolutionary and structural proteomics to identify potential drug targets. Opportunities and challenges for the design of drugs for M. tuberculosis, M. leprae and M. abscessus combat resistance are discussed.

Precision Balance - 320gm

LB323-1NO 1 unit
EUR 642.44
Description: Precision Balance - 320gm

Precision Balance - 320gm

LB323C-1NO 1 unit
EUR 825.98
Description: Precision Balance - 320gm

Precision Balance - 420gm

LB423C-1NO 1 unit
EUR 954.49
Description: Precision Balance - 420gm

Precision Balance - 720gm

LB723C-1NO 1 unit
EUR 1395
Description: Precision Balance - 720gm

Opti-Protein Precision Marker

E36G622 500 μl/100 loads
EUR 100

Scout Precision Balance 220 g

BAL0043 EACH
EUR 555.12

Scout Precision Balance 420 g

BAL0048 EACH
EUR 313.2

Scout Precision Balance 620 g

BAL0049 EACH
EUR 362.88

Precision Balance 2200g (0.1g) - EACH

BAL1190 EACH
EUR 1404

Precision Balance 5200g (0.1g) - EACH

BAL1192 EACH
EUR 1559.25

Precision Balance 8200g (0.1g) - EACH

BAL1194 EACH
EUR 1707.75

Precision Balance 6200g (1g) - EACH

BAL1196 EACH
EUR 1404

Precision Balance 8200g (1g) - EACH

BAL1198 EACH
EUR 1559.25

Precision Balance 220g (1mg) - EACH

BAL1166 EACH
EUR 1404

Precision Balance 320g (1mg) - EACH

BAL1168 EACH
EUR 1559.25

Precision Balance 420g (1mg) - EACH

BAL1170 EACH
EUR 1707.75

Precision Balance 620g (1mg) - EACH

BAL1172 EACH
EUR 2004.75

Precision Balance 650g (1mg) - EACH

BAL1174 EACH
EUR 2301.75

Precision Balance, 120 grams, 115V

BCM1306 1 pcs, 1 UNIT
EUR 1458.49

Precision Balance, 320 grams, 115V

BCM1307 1 pcs, 1 UNIT
EUR 1547.23

Precision Balance, 500 grams, 115V

BCM1308 1 pcs, 1 UNIT
EUR 1775

Precision Balance, 1200 grams, 115V

BCM1309 1 pcs, 1 UNIT
EUR 1458.49

Precision Balance, 3200 grams, 115V

BCM1310 1 pcs, 1 UNIT
EUR 1547.23

Precision Balance, 5000 grams, 115V

BCM1311 1 pcs, 1 UNIT
EUR 2115.17

Precision Balance 620g (10mg) - EACH

BAL1176 EACH
EUR 1259.55

Precision Balance 820g (10mg) - EACH

BAL1178 EACH
EUR 1404

Precision Balance 1200g (10mg) - EACH

BAL1180 EACH
EUR 1559.25

Precision Balance 2200g (10mg) - EACH

BAL1182 EACH
EUR 1707.75

Precision Balance 3200g (10mg) - EACH

BAL1184 EACH
EUR 1856.25

Precision Balance 4200g (10mg) - EACH

BAL1186 EACH
EUR 2004.75

Precision Balance 6200g (10mg) - EACH

BAL1188 EACH
EUR 2301.75

KC Kimtech precision wipes - PK30

CLE7552 PK30
EUR 261.9

Scout Precision Balance 2200g - EACH

BAL0047 EACH
EUR 580.5

2X PCR Precision™ MasterMix

G124 5.0 ml (200 Rxns)
EUR 195.6

20mL Precision Thread Vial - PK1000

CHR2676 PK1000
EUR 664.2

Precision™ DNA Polymerase (PCR)

G078 500 U (100 ul)
EUR 133.2

Scout Precision Balance 120 g - EACH

BAL0041 EACH
EUR 920.7

Scout Precision Balance 220 g - EACH

BAL0042 EACH
EUR 1067.85

Scout Precision Balance 420 g - EACH

BAL0044 EACH
EUR 831.6

Scout Precision Balance 620 g - EACH

BAL0045 EACH
EUR 908.55

Scout Precision Balance 1200 g - EACH

BAL0046 EACH
EUR 999

Scout Precision Balance 2200 g - EACH

BAL0050 EACH
EUR 683.1

Scout Precision Balance 6200 g - EACH

BAL0051 EACH
EUR 876.15

Scout Precision Balance 8200 g - EACH

BAL0052 EACH
EUR 669.6

Precision Balance int.cal. 2200g (0.1g) - EACH

BAL1044 EACH
EUR 1711.8

Precision Balance int.cal. 5200g (0.1g) - EACH

BAL1046 EACH
EUR 1846.8

Precision Balance int.cal. 8200g (0.1g) - EACH

BAL1048 EACH
EUR 1981.8

Precision Balance int.cal. 6200g (1g) - EACH

BAL1096 EACH
EUR 1711.8

Precision Balance int.cal. 8200g (1g) - EACH

BAL1098 EACH
EUR 1846.8

1ml Precision FAST qPCR Master Mix

Z-PFAST-1ML 1ml
EUR 90
Description: Precision®FAST

2ml Precision FAST qPCR Master Mix

Z-PFAST-2ML 2ml
EUR 161
Description: Precision®FAST

Precision Balance int.cal. 220g (1mg) - EACH

BAL1002 EACH
EUR 1711.8

Precision Balance int.cal. 320g (1mg) - EACH

BAL1004 EACH
EUR 1846.8

Precision Balance int.cal. 420g (1mg) - EACH

BAL1006 EACH
EUR 1981.8

Precision Balance int.cal. 620g (1mg) - EACH

BAL1008 EACH
EUR 2266.65

Precision Balance int.cal. 650g (1mg) - EACH

BAL1024 EACH
EUR 2566.35

Precision Balance int.cal. 620g (10mg) - EACH

BAL1026 EACH
EUR 1548.45

Precision Balance int.cal. 820g (10mg) - EACH

BAL1028 EACH
EUR 1711.8

Precision Balance int.cal. 1200g (10mg) - EACH

BAL1032 EACH
EUR 1846.8

Precision Balance int.cal. 2200g (10mg) - EACH

BAL1034 EACH
EUR 1981.8

Precision Balance int.cal. 3200g (10mg) - EACH

BAL1036 EACH
EUR 2434.05

Precision Balance int.cal. 4200g (10mg) - EACH

BAL1038 EACH
EUR 2266.65

Precision Balance int.cal. 6200g (10mg) - EACH

BAL1042 EACH
EUR 2566.35

Precision Wipes POPUP Box Large - PK15

CLE3408 PK15
EUR 373.95

PX523 Precision Balance. 520g (0.001g). InCal

BAL1326 EACH
EUR 1242.6

PX523M Precision Balance. 520g (0.001g). InCal

BAL1328 EACH
EUR 1413.6

PX5202 Precision Balance. 5200g (0.01g). InCal

BAL1338 EACH
EUR 1254

10mL Precision Vial Clear Glass - PK1000

CHR2646 PK1000
EUR 540

1ml Precision FAST CL qPCR Master Mix

Z-PFAST-CL-1ML 1ml
EUR 90
Description: Precision®FAST

2ml Precision FAST CL qPCR Master Mix

Z-PFAST-CL-2ML 2ml
EUR 161
Description: Precision®FAST

1ml Precision FAST LR qPCR Master Mix

Z-PFAST-LR-1ML 1ml
EUR 90
Description: Precision®FAST

PX5202M Precision Balance. 5200g (0.01g). InCal

BAL1404 EACH
EUR 1453.5

2 ml Precision FAST LR qPCR Master Mix

Z-PFAST-LR-2ML 2ml
EUR 161
Description: Precision®FAST

PX523/E Precision Balance. 520g (0.001g). ExCal

BAL1324 EACH
EUR 1026

1ml Precision FAST CL & SY qPCR Master Mix

Z-PFAST-CL-SY-1ML 1ml
EUR 90
Description: Precision®FAST

2ml Precision FAST CL & SY qPCR Master Mix

Z-PFAST-CL-SY-2ML 2ml
EUR 161
Description: Precision®FAST

1ml Precision FAST iC & SY qPCR Master Mix

Z-PFAST-iC-SY-1ML 1ml
EUR 90
Description: Precision®FAST

2ml Precision FAST iC & SY qPCR Master Mix

Z-PFAST-iC-SY-2ML 2ml
EUR 161
Description: Precision®FAST

1ml Precision FAST LR & SY qPCR Master Mix

Z-PFAST-LR-SY-1ML 1ml
EUR 90
Description: Precision®FAST

2ml Precision FAST LR & SY qPCR Master Mix

Z-PFAST-LR-SY-2ML 2ml
EUR 161
Description: Precision®FAST

1ml Precision FAST MX & SY qPCR Master Mix

Z-PFAST-MX-SY-1ML 1ml
EUR 90
Description: Precision®FAST

2ml Precision FAST MX & SY qPCR Master Mix

Z-PFAST-MX-SY-2ML 2ml
EUR 161
Description: Precision®FAST

1ml Precision FAST R & SY qPCR Master Mix

Z-PFAST-R-SY-1ML 1ml
EUR 90
Description: Precision®FAST

2ml Precision FAST R & SY qPCR Master Mix

Z-PFAST-R-SY-2ML 2ml
EUR 161
Description: Precision®FAST

PX5202/E Precision Balance. 5200g (0.01g). ExCal

BAL1336 EACH
EUR 1054.5

2X PCR Precision™ MasterMix with dye

G124-dye 5.0 ml (200 Rxns)
EUR 195.6

Tweezer, Titanium, Micro Fine Tip Fine Precision, 115mm

43260013-1 1 Each
EUR 94.4

PX323 Precision Balance. 320g (0.001g). InCal - EACH

BAL1320 EACH
EUR 1537.65

PX4201 Precision Balance. 4200g (0.1g). InCal - EACH

BAL1408 EACH
EUR 1490.4

PX323M Precision Balance. 320g (0.001g). InCal - EACH

BAL1322 EACH
EUR 1784.7

PX3202 Precision Balance. 3200g (0.01g). InCal - EACH

BAL1332 EACH
EUR 1582.2

Precision syringe 250ul with drain tube - EACH

WAT4840 EACH
EUR 737.34

Precision nanoScript 2 RT kit. 50 reactions

Z-RT-nanoScript2 50 tests
EUR 340

Precision nanoScript 2 RT kit. 150 reactions

Z-RT-nanoScript2-150 150 tests
EUR 925

1ml Precision FAST qPCR Master Mix with ROX

Z-PFAST-R-1ML 1ml
EUR 90
Description: Precision®FAST

2ml Precision FAST qPCR Master Mix with ROX

Z-PFAST-R-2ML 2ml
EUR 161
Description: Precision®FAST

PX3202M Precision Balance. 3200g (0.01g). InCal - EACH

BAL1334 EACH
EUR 1864.35

Precision Red Advanced Protein Assay (1X conc)

ADV02-A 1 x 500 ml
EUR 154.96

Precision Red Advanced Protein Assay (1X conc)

ADV02-B 3 x 500 ml
EUR 399.36

AX223 220g 1mg Int Cal Precision Balance - EACH

BAL0015 EACH
EUR 2470.5

AX423 420g 1mg Int Cal Precision Balance - EACH

BAL0017 EACH
EUR 2722.95

AX523 520g 1mg Int Cal Precision Balance - EACH

BAL0019 EACH
EUR 3244.05

5ml Precision FAST qPCR Master Mix (5 x 1ml)

Z-PFAST-5ML 5ml
EUR 348
Description: Precision®FAST

AX1502 1520g 0.01g Int Cal Precision Balance - EACH

BAL0023 EACH
EUR 2442.15

AX2202 2200g 0.01g Int Cal Precision Balance - EACH

BAL0025 EACH
EUR 2485.35

AX4202 4200g 0.01g Int Cal Precision Balance - EACH

BAL0027 EACH
EUR 2668.95

AX5202 5200g 0.01g Int Cal Precision Balance - EACH

BAL0029 EACH
EUR 3244.05

PX323/E Precision Balance. 320g (0.001g). ExCal - EACH

BAL1318 EACH
EUR 1188

PX4201/E Precision Balance. 4200g (0.1g). ExCal - EACH

BAL1406 EACH
EUR 1213.65

10ml Precision FAST qPCR Master Mix (10 x 1ml)

Z-PFAST-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST qPCR Master Mix (20 x 1ml)

Z-PFAST-20ML 20ml
EUR 1120
Description: Precision®FAST

PX3202/E Precision Balance. 3200g (0.01g). ExCal - EACH

BAL1330 EACH
EUR 1221.75

5ml Precision FAST CL qPCR Master Mix (5 x 1ml)

Z-PFAST-CL-5ML 5ml
EUR 348
Description: Precision®FAST

5ml Precision FAST iC qPCR Master Mix (5 x 1ml)

Z-PFAST-iC-5ML 5ml
EUR 348
Description: Precision®FAST

5ml Precision FAST LR qPCR Master Mix (5 x 1ml)

Z-PFAST-LR-5ML 5ml
EUR 348
Description: Precision®FAST

5ml Precision FAST MX qPCR Master Mix (5 x 1ml)

Z-PFAST-MX-5ML 5ml
EUR 348
Description: Precision®FAST

5ml Precision FAST SY qPCR Master Mix (5 x 1ml)

Z-PFAST-SY-5ML 5ml
EUR 348
Description: Precision®FAST

Blue dye for adding to 1ml Precision Master Mix

Z-BLUEDYE-1ML 8µl
EUR 33

Blue dye for adding to 2ml Precision Master Mix

Z-BLUEDYE-2ML 12µl
EUR 38

Blue dye for adding to 5ml Precision Master Mix

Z-BLUEDYE-5ML 30µl
EUR 46

10ml Precision FAST CL qPCR Master Mix (10 x 1ml)

Z-PFAST-CL-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST CL qPCR Master Mix(20 x 1ml)

Z-PFAST-CL-20ML 20ml
EUR 1120
Description: Precision®FAST

10ml Precision FAST iC qPCR Master Mix (10 x 1ml)

Z-PFAST-iC-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST iC qPCR Master Mix (20 x 1ml)

Z-PFAST-iC-20ML 20ml
EUR 1120
Description: Precision®FAST

10ml Precision FAST LR qPCR Master Mix (10 x 1ml)

Z-PFAST-LR-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST LR qPCR Master Mix (20 x 1ml)

Z-PFAST-LR-20ML 20ml
EUR 1120
Description: Precision®FAST

10ml Precision FAST MX qPCR Master Mix (10 x 1ml)

Z-PFAST-MX-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST MX qPCR Master Mix (20 x 1ml)

Z-PFAST-MX-20ML 20ml
EUR 1120
Description: Precision®FAST

10ml Precision FAST SY qPCR Master Mix (10 x 1ml)

Z-PFAST-SY-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST SY qPCR Master Mix (20 x 1ml)

Z-PFAST-SY-20ML 20ml
EUR 1120
Description: Precision®FAST

Blue dye for adding to 10ml Precision Master Mix

Z-BLUEDYE-10ML 60µl
EUR 69

Blue dye for adding to 20ml Precision Master Mix

Z-BLUEDYE-20ML 115µl
EUR 105

Sample Precision nanoScript 2 RT kit. 10 reactions

Z-RT-nanoScript2-sample 10 tests Ask for price

5ml Precision FAST CL & SY qPCR Master Mix (5 x 1ml)

Z-PFAST-CL-SY-5ML 5ml
EUR 348
Description: Precision®FAST

5ml Precision FAST iC & SY qPCR Master Mix (5 x 1ml)

Z-PFAST-iC-SY-5ML 5ml
EUR 348
Description: Precision®FAST

5ml Precision FAST LR & SY qPCR Master Mix (5 x 1ml)

Z-PFAST-LR-SY-5ML 5ml
EUR 348
Description: Precision®FAST

5ml Precision FAST MX & SY qPCR Master Mix (5 x 1ml)

Z-PFAST-MX-SY-5ML 5ml
EUR 348
Description: Precision®FAST

5ml Precision FAST R & SY qPCR Master Mix (5 x 1ml)

Z-PFAST-R-SY-5ML 5ml
EUR 348
Description: Precision®FAST

10ml Precision FAST CL & SY qPCR Master Mix (10 x 1ml)

Z-PFAST-CL-SY-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST CL & SY qPCR Master Mix (20 x 1ml)

Z-PFAST-CL-SY-20ML 20ml
EUR 1120
Description: Precision®FAST

10ml Precision FAST iC & SY qPCR Master Mix (10 x 1ml)

Z-PFAST-iC-SY-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST iC & SY qPCR Master Mix (20 x 1ml)

Z-PFAST-iC-SY-20ML 20ml
EUR 1120
Description: Precision®FAST

10ml Precision FAST LR & SY qPCR Master Mix (10 x 1ml)

Z-PFAST-LR-SY-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST LR & SY qPCR Master Mix (20 x 1ml)

Z-PFAST-LR-SY-20ML 20ml
EUR 1120
Description: Precision®FAST

10ml Precision FAST MX & SY qPCR Master Mix (10 x 1ml)

Z-PFAST-MX-SY-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST MX & SY qPCR Master Mix (20 x 1ml)

Z-PFAST-MX-SY-20ML 20ml
EUR 1120
Description: Precision®FAST

10ml Precision FAST R & SY qPCR Master Mix (10 x 1ml)

Z-PFAST-R-SY-10ML 10ml
EUR 641
Description: Precision®FAST

20ml Precision FAST R & SY qPCR Master Mix (20 x 1ml)

Z-PFAST-R-SY-20ML 20ml
EUR 1120
Description: Precision®FAST

Precision qPCR endogenous control for Sus scrofa (Pig)

Z-EC-S.scrofa 150 rxns
EUR 198
Description: S.scrofa

Precision qPCR endogenous control for Saccharomycetales

Z-EC-Saccharomycetales 150 tests
EUR 198
Description: Endogenous control

5ml Precision FAST qPCR Master Mix with ROX (5 x 1ml)

Z-PFAST-R-5ML 5ml
EUR 348
Description: Precision®FAST

Ohaus PR Series Precision Balances PR223 220g (0.001g) - EACH

BAL1490 EACH
EUR 1170.45

Ohaus PR Series Precision Balances PR423 420g (0.001g) - EACH

BAL1494 EACH
EUR 1120.5

Ohaus PR Series Precision Balances PR523 520g (0.001g) - EACH

BAL1498 EACH
EUR 1256.85

Ohaus PR Series Precision Balances PR4201 4200g (0.1g) - EACH

BAL1574 EACH
EUR 1120.5

Ohaus PR Series Precision Balances PR6201 6200g (0.1g) - EACH

BAL1578 EACH
EUR 1148.85