Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery.

Of the more than 190 different species of the genus Mycobacterium, many of which are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species are Mycobacterium tuberculosis (the agent causing tuberculosis), Mycobacterium leprae (leprosy-causing agents) and Mycobacterium abscessus (agents causing chronic lung infections) pose a concern for global public health.

Although antibiotics have been developed to combat each, the emergence of drug-resistant strains is an increasing challenge for medicine and drug discovery. Here we describe the impact of the rapid expansion of genome sequencing and genome / explanation which has greatly improved track progress structure-guided drug discovery.

We focus on the application of comparative genomics, metabolomics, bioinformatics evolutionary and structural proteomics to identify potential drug targets. Opportunities and challenges for the design of drugs for M. tuberculosis, M. leprae and M. abscessus combat resistance are discussed.

Precision Balance 8200g (1g)

BAL1198 EACH
EUR 1386

Precision Balance 220g (1mg)

BAL1166 EACH
EUR 1248

Precision Balance 320g (1mg)

BAL1168 EACH
EUR 1386

Precision Balance 420g (1mg)

BAL1170 EACH
EUR 1518

Precision Balance 620g (1mg)

BAL1172 EACH
EUR 1782

Precision Balance 650g (1mg)

BAL1174 EACH
EUR 2046

Precision Balance 620g (10mg)

BAL1176 EACH
EUR 1119.6

Precision Balance 820g (10mg)

BAL1178 EACH
EUR 1248

Precision Balance 1200g (10mg)

BAL1180 EACH
EUR 1386

Precision Balance 2200g (10mg)

BAL1182 EACH
EUR 1518

Precision Balance 3200g (10mg)

BAL1184 EACH
EUR 1650

Precision Balance 4200g (10mg)

BAL1186 EACH
EUR 1782

Precision Balance 6200g (10mg)

BAL1188 EACH
EUR 2046

KC Kimtech precision wipes

CLE7552 PK30
EUR 232.8

20mL Precision Thread Vial

CHR2676 PK1000
EUR 590.4

Scout Precision Balance 2200g

BAL0047 EACH
EUR 516

Scout Precision Balance 120 g

BAL0041 EACH
EUR 818.4

Scout Precision Balance 220 g

BAL0042 EACH
EUR 949.2

Scout Precision Balance 220 g

BAL0043 EACH
EUR 616.8

Scout Precision Balance 420 g

BAL0044 EACH
EUR 739.2

Scout Precision Balance 620 g

BAL0045 EACH
EUR 807.6

Scout Precision Balance 1200 g

BAL0046 EACH
EUR 888

Scout Precision Balance 420 g

BAL0048 EACH
EUR 348

Scout Precision Balance 620 g

BAL0049 EACH
EUR 403.2

Scout Precision Balance 2200 g

BAL0050 EACH
EUR 607.2

Scout Precision Balance 6200 g

BAL0051 EACH
EUR 778.8

Scout Precision Balance 8200 g

BAL0052 EACH
EUR 595.2

Precision Balance int.cal. 2200g (0.1g)

BAL1044 EACH
EUR 1521.6

Precision Balance int.cal. 5200g (0.1g)

BAL1046 EACH
EUR 1641.6

Precision Balance int.cal. 8200g (0.1g)

BAL1048 EACH
EUR 1761.6

Precision Balance int.cal. 6200g (1g)

BAL1096 EACH
EUR 1521.6

Precision Balance int.cal. 8200g (1g)

BAL1098 EACH
EUR 1641.6

Opti-Protein Precision Marker

E36G622 500 μl/100 loads
EUR 100

Precision Balance int.cal. 220g (1mg)

BAL1002 EACH
EUR 1521.6

Precision Balance int.cal. 320g (1mg)

BAL1004 EACH
EUR 1641.6

Precision Balance int.cal. 420g (1mg)

BAL1006 EACH
EUR 1761.6

Precision Balance int.cal. 620g (1mg)

BAL1008 EACH
EUR 2014.8

Precision Balance int.cal. 650g (1mg)

BAL1024 EACH
EUR 2281.2

Precision Balance, 120 grams, 115V

BCM1306 1 pcs, 1 UNIT
EUR 1458.49

Precision Balance, 320 grams, 115V

BCM1307 1 pcs, 1 UNIT
EUR 1547.23

Precision Balance, 500 grams, 115V

BCM1308 1 pcs, 1 UNIT
EUR 1775

Precision Balance, 1200 grams, 115V

BCM1309 1 pcs, 1 UNIT
EUR 1458.49

Precision Balance, 3200 grams, 115V

BCM1310 1 pcs, 1 UNIT
EUR 1547.23

Precision Balance, 5000 grams, 115V

BCM1311 1 pcs, 1 UNIT
EUR 2115.17

Precision Balance int.cal. 620g (10mg)

BAL1026 EACH
EUR 1376.4

Precision Balance int.cal. 820g (10mg)

BAL1028 EACH
EUR 1521.6

Precision Balance int.cal. 1200g (10mg)

BAL1032 EACH
EUR 1641.6

Precision Balance int.cal. 2200g (10mg)

BAL1034 EACH
EUR 1761.6

Precision Balance int.cal. 3200g (10mg)

BAL1036 EACH
EUR 2163.6

Precision Balance int.cal. 4200g (10mg)

BAL1038 EACH
EUR 2014.8

Precision Balance int.cal. 6200g (10mg)

BAL1042 EACH
EUR 2281.2

Precision Wipes POPUP Box Large

CLE3408 PK15
EUR 332.4

10mL Precision Vial Clear Glass

CHR2646 PK1000
EUR 480

2X PCR Precision™ MasterMix

G124 5.0 ml (200 Rxns)
EUR 195.6

Precision™ DNA Polymerase (PCR)

G078 500 U (100 ul)
EUR 133.2

PX323 Precision Balance. 320g (0.001g). InCal

BAL1320 EACH
EUR 1366.8

PX523 Precision Balance. 520g (0.001g). InCal

BAL1326 EACH
EUR 1242.6

PX4201 Precision Balance. 4200g (0.1g). InCal

BAL1408 EACH
EUR 1324.8

PX323M Precision Balance. 320g (0.001g). InCal

BAL1322 EACH
EUR 1586.4

PX523M Precision Balance. 520g (0.001g). InCal

BAL1328 EACH
EUR 1413.6

PX3202 Precision Balance. 3200g (0.01g). InCal

BAL1332 EACH
EUR 1406.4

PX5202 Precision Balance. 5200g (0.01g). InCal

BAL1338 EACH
EUR 1254

Precision syringe 250ul with drain tube

WAT4840 EACH
EUR 655.41

PX3202M Precision Balance. 3200g (0.01g). InCal

BAL1334 EACH
EUR 1657.2

PX5202M Precision Balance. 5200g (0.01g). InCal

BAL1404 EACH
EUR 1453.5

AX223 220g 1mg Int Cal Precision Balance

BAL0015 EACH
EUR 2196

AX423 420g 1mg Int Cal Precision Balance

BAL0017 EACH
EUR 2420.4

AX523 520g 1mg Int Cal Precision Balance

BAL0019 EACH
EUR 2883.6

AX1502 1520g 0.01g Int Cal Precision Balance

BAL0023 EACH
EUR 2170.8

AX2202 2200g 0.01g Int Cal Precision Balance

BAL0025 EACH
EUR 2209.2

AX4202 4200g 0.01g Int Cal Precision Balance

BAL0027 EACH
EUR 2372.4

AX5202 5200g 0.01g Int Cal Precision Balance

BAL0029 EACH
EUR 2883.6

PX323/E Precision Balance. 320g (0.001g). ExCal

BAL1318 EACH
EUR 1056

PX523/E Precision Balance. 520g (0.001g). ExCal

BAL1324 EACH
EUR 1026

PX4201/E Precision Balance. 4200g (0.1g). ExCal

BAL1406 EACH
EUR 1078.8

PX3202/E Precision Balance. 3200g (0.01g). ExCal

BAL1330 EACH
EUR 1086

PX5202/E Precision Balance. 5200g (0.01g). ExCal

BAL1336 EACH
EUR 1054.5

2X PCR Precision™ MasterMix with dye

G124-dye 5.0 ml (200 Rxns)
EUR 195.6

Tweezer, Titanium, Micro Fine Tip Fine Precision, 115mm

43260013-1 1 Each
EUR 94.4

Ohaus PR Series Precision Balances PR223 220g (0.001g)

BAL1490 EACH
EUR 1040.4

Ohaus PR Series Precision Balances PR423 420g (0.001g)

BAL1494 EACH
EUR 996

Ohaus PR Series Precision Balances PR523 520g (0.001g)

BAL1498 EACH
EUR 1117.2

Ohaus PR Series Precision Balances PR4201 4200g (0.1g)

BAL1574 EACH
EUR 996

Ohaus PR Series Precision Balances PR6201 6200g (0.1g)

BAL1578 EACH
EUR 1021.2

Ohaus PR Series Precision Balances PR1602 1600g (0.01g)

BAL1562 EACH
EUR 1066.8

Ohaus PR Series Precision Balances PR2202 2200g (0.01g)

BAL1566 EACH
EUR 1096.8

Ohaus PR Series Precision Balances PR4202 4200g (0.01g)

BAL1570 EACH
EUR 1068

SLS Lab Basics Compact Precision Balance 3100g x 0.1g

SLS5068 EACH
EUR 423.6

SLS Lab Pro P-Series Precision Balance 320g x 0.001g

SLS5062 EACH
EUR 1317.6

SLS Lab Pro P-Series Precision Balance 3200g x 0.01g

SLS5064 EACH
EUR 1317.6

Ohaus PR Series Precision Balances PR223/E 220g (0.001g)

BAL1488 EACH
EUR 854.4

Ohaus PR Series Precision Balances PR423/E 420g (0.001g)

BAL1492 EACH
EUR 873.6

Ohaus PR Series Precision Balances PR523/E 520g (0.001g)

BAL1496 EACH
EUR 919.2

Ohaus PR Series Precision Balances PR4201/E 4200g (0.1g)

BAL1572 EACH
EUR 796.8

Ohaus PR Series Precision Balances PR6201/E 6200g (0.1g)

BAL1576 EACH
EUR 835.2

SLS Lab Basics Compact Precision Balance 310g x 0.01g

SLS5066 EACH
EUR 362.4

Ohaus PR Series Precision Balances PR1602/E 1600g (0.01g)

BAL1548 EACH
EUR 873.6

Ohaus PR Series Precision Balances PR2202/E 2200g (0.01g)

BAL1564 EACH
EUR 891.6

Ohaus PR Series Precision Balances PR4202/E 4200g (0.01g)

BAL1568 EACH
EUR 882

Accuris™ Precision Balance, 120 grams, readability 0.001grams, 115V

W3200-120 1 each
EUR 1116.2

Accuris™ Precision Balance, 120 grams, readability 0.001grams, 230V

W3200-120-E 1 PC
EUR 1116.2

Accuris™ Precision Balance, 1200 grams, readability 0.01grams, 115V

W3200-1200 1 each
EUR 1121.9

Accuris™ Precision Balance, 1200 grams, readability 0.01grams, 230V

W3200-1200-E 1 PC
EUR 1121.9

Accuris™ Precision Balance, 320 grams, readability 0.001grams, 115V

W3200-320 1 each
EUR 1196.3

Accuris™ Precision Balance, 320 grams, readability 0.001grams, 230V

W3200-320-E 1 PC
EUR 1196.3

Accuris™ Precision Balance, 3200 grams, readability 0.01grams, 115V

W3200-3200 1 each
EUR 1196.3

Accuris™ Precision Balance, 3200 grams, readability 0.01grams, 230V

W3200-3200-E 1 PC
EUR 1196.3

Accuris™ Precision Balance, 500 grams, readability 0.001grams, 115V

W3200-500 1 each
EUR 1385.2

Accuris™ Precision Balance, 500 grams, readability 0.001grams, 230V

W3200-500-E 1 PC
EUR 1385.2

Accuris™ Precision Balance, 5000 grams, readability 0.01grams, 115V

W3200-5K 1 each
EUR 1648.5

Accuris™ Precision Balance, 5000 grams, readability 0.01grams, 230V

W3200-5K-E 1 PC
EUR 1648.5

Tweezers, Rubis Ultra Fine Straight Pointed Precision Tip, 120mm, 4.75€

25045-1 1EA
EUR 49

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long

NMR1129 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long

NMR1130 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long

NMR1131 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long

NMR1132 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long

NMR1133 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long

NMR1134 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long

NMR1141 EACH
EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long

NMR1142 EACH
EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long

NMR1143 EACH
EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long

NMR1144 EACH
EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long

NMR1145 EACH
EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long

NMR1146 EACH
EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long

NMR1153 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long

NMR1154 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long

NMR1155 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long

NMR1156 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long

NMR1157 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long

NMR1158 EACH
EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long

NMR1165 EACH
EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long

NMR1166 EACH
EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long

NMR1167 EACH
EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long

NMR1168 EACH
EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long

NMR1169 EACH
EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long

NMR1170 EACH
EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long

NMR1177 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long

NMR1178 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long

NMR1179 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long

NMR1180 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long

NMR1181 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long

NMR1182 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long

NMR1189 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long

NMR1190 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long

NMR1191 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long

NMR1192 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long

NMR1193 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long

NMR1194 EACH
EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long

NMR1201 EACH
EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long

NMR1202 EACH
EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long

NMR1203 EACH
EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long

NMR1204 EACH
EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long

NMR1205 EACH
EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long

NMR1206 EACH
EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 7 Long

NMR1213 EACH
EUR 122.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 7 Long

NMR1214 EACH
EUR 122.4