Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery.

Of the more than 190 different species of the genus Mycobacterium, many of which are economically and clinically important pathogens of humans or animals. Among those mycobacteria that infect humans, three species are Mycobacterium tuberculosis (the agent causing tuberculosis), Mycobacterium leprae (leprosy-causing agents) and Mycobacterium abscessus (agents causing chronic lung infections) pose a concern for global public health.

Although antibiotics have been developed to combat each, the emergence of drug-resistant strains is an increasing challenge for medicine and drug discovery. Here we describe the impact of the rapid expansion of genome sequencing and genome / explanation which has greatly improved track progress structure-guided drug discovery.

We focus on the application of comparative genomics, metabolomics, bioinformatics evolutionary and structural proteomics to identify potential drug targets. Opportunities and challenges for the design of drugs for M. tuberculosis, M. leprae and M. abscessus combat resistance are discussed.

Precision Balance 8200g (1g)
BAL1198	Scientific Laboratory Supplies	EACH	EUR 1386

Precision Balance 220g (1mg)
BAL1166	Scientific Laboratory Supplies	EACH	EUR 1248

Precision Balance 320g (1mg)
BAL1168	Scientific Laboratory Supplies	EACH	EUR 1386

Precision Balance 420g (1mg)
BAL1170	Scientific Laboratory Supplies	EACH	EUR 1518

Precision Balance 620g (1mg)
BAL1172	Scientific Laboratory Supplies	EACH	EUR 1782

Precision Balance 650g (1mg)
BAL1174	Scientific Laboratory Supplies	EACH	EUR 2046

Precision Balance 620g (10mg)
BAL1176	Scientific Laboratory Supplies	EACH	EUR 1119.6

Precision Balance 820g (10mg)
BAL1178	Scientific Laboratory Supplies	EACH	EUR 1248

Precision Balance 1200g (10mg)
BAL1180	Scientific Laboratory Supplies	EACH	EUR 1386

Precision Balance 2200g (10mg)
BAL1182	Scientific Laboratory Supplies	EACH	EUR 1518

Precision Balance 3200g (10mg)
BAL1184	Scientific Laboratory Supplies	EACH	EUR 1650

Precision Balance 4200g (10mg)
BAL1186	Scientific Laboratory Supplies	EACH	EUR 1782

Precision Balance 6200g (10mg)
BAL1188	Scientific Laboratory Supplies	EACH	EUR 2046

KC Kimtech precision wipes
CLE7552	Scientific Laboratory Supplies	PK30	EUR 232.8

20mL Precision Thread Vial
CHR2676	Scientific Laboratory Supplies	PK1000	EUR 590.4

Scout Precision Balance 2200g
BAL0047	Scientific Laboratory Supplies	EACH	EUR 516

Scout Precision Balance 120 g
BAL0041	Scientific Laboratory Supplies	EACH	EUR 818.4

Scout Precision Balance 220 g
BAL0042	Scientific Laboratory Supplies	EACH	EUR 949.2

Scout Precision Balance 220 g
BAL0043	Scientific Laboratory Supplies	EACH	EUR 616.8

Scout Precision Balance 420 g
BAL0044	Scientific Laboratory Supplies	EACH	EUR 739.2

Scout Precision Balance 620 g
BAL0045	Scientific Laboratory Supplies	EACH	EUR 807.6

Scout Precision Balance 1200 g
BAL0046	Scientific Laboratory Supplies	EACH	EUR 888

Scout Precision Balance 420 g
BAL0048	Scientific Laboratory Supplies	EACH	EUR 348

Scout Precision Balance 620 g
BAL0049	Scientific Laboratory Supplies	EACH	EUR 403.2

Scout Precision Balance 2200 g
BAL0050	Scientific Laboratory Supplies	EACH	EUR 607.2

Scout Precision Balance 6200 g
BAL0051	Scientific Laboratory Supplies	EACH	EUR 778.8

Scout Precision Balance 8200 g
BAL0052	Scientific Laboratory Supplies	EACH	EUR 595.2

Precision Balance int.cal. 2200g (0.1g)
BAL1044	Scientific Laboratory Supplies	EACH	EUR 1521.6

Precision Balance int.cal. 5200g (0.1g)
BAL1046	Scientific Laboratory Supplies	EACH	EUR 1641.6

Precision Balance int.cal. 8200g (0.1g)
BAL1048	Scientific Laboratory Supplies	EACH	EUR 1761.6

Precision Balance int.cal. 6200g (1g)
BAL1096	Scientific Laboratory Supplies	EACH	EUR 1521.6

Precision Balance int.cal. 8200g (1g)
BAL1098	Scientific Laboratory Supplies	EACH	EUR 1641.6

Opti-Protein Precision Marker
E36G622	EnoGene	500 μl/100 loads	EUR 100

Precision Balance int.cal. 220g (1mg)
BAL1002	Scientific Laboratory Supplies	EACH	EUR 1521.6

Precision Balance int.cal. 320g (1mg)
BAL1004	Scientific Laboratory Supplies	EACH	EUR 1641.6

Precision Balance int.cal. 420g (1mg)
BAL1006	Scientific Laboratory Supplies	EACH	EUR 1761.6

Precision Balance int.cal. 620g (1mg)
BAL1008	Scientific Laboratory Supplies	EACH	EUR 2014.8

Precision Balance int.cal. 650g (1mg)
BAL1024	Scientific Laboratory Supplies	EACH	EUR 2281.2

Precision Balance, 120 grams, 115V
BCM1306	Bio Basic	1 pcs, 1 UNIT	EUR 1458.49

Precision Balance, 320 grams, 115V
BCM1307	Bio Basic	1 pcs, 1 UNIT	EUR 1547.23

Precision Balance, 500 grams, 115V
BCM1308	Bio Basic	1 pcs, 1 UNIT	EUR 1775

Precision Balance, 1200 grams, 115V
BCM1309	Bio Basic	1 pcs, 1 UNIT	EUR 1458.49

Precision Balance, 3200 grams, 115V
BCM1310	Bio Basic	1 pcs, 1 UNIT	EUR 1547.23

Precision Balance, 5000 grams, 115V
BCM1311	Bio Basic	1 pcs, 1 UNIT	EUR 2115.17

Precision Balance int.cal. 620g (10mg)
BAL1026	Scientific Laboratory Supplies	EACH	EUR 1376.4

Precision Balance int.cal. 820g (10mg)
BAL1028	Scientific Laboratory Supplies	EACH	EUR 1521.6

Precision Balance int.cal. 1200g (10mg)
BAL1032	Scientific Laboratory Supplies	EACH	EUR 1641.6

Precision Balance int.cal. 2200g (10mg)
BAL1034	Scientific Laboratory Supplies	EACH	EUR 1761.6

Precision Balance int.cal. 3200g (10mg)
BAL1036	Scientific Laboratory Supplies	EACH	EUR 2163.6

Precision Balance int.cal. 4200g (10mg)
BAL1038	Scientific Laboratory Supplies	EACH	EUR 2014.8

Precision Balance int.cal. 6200g (10mg)
BAL1042	Scientific Laboratory Supplies	EACH	EUR 2281.2

Precision Wipes POPUP Box Large
CLE3408	Scientific Laboratory Supplies	PK15	EUR 332.4

10mL Precision Vial Clear Glass
CHR2646	Scientific Laboratory Supplies	PK1000	EUR 480

2X PCR Precision™ MasterMix
G124	ABM	5.0 ml (200 Rxns)	EUR 195.6

Precision™ DNA Polymerase (PCR)
G078	ABM	500 U (100 ul)	EUR 133.2

PX323 Precision Balance. 320g (0.001g). InCal
BAL1320	Scientific Laboratory Supplies	EACH	EUR 1366.8

PX523 Precision Balance. 520g (0.001g). InCal
BAL1326	Scientific Laboratory Supplies	EACH	EUR 1242.6

PX4201 Precision Balance. 4200g (0.1g). InCal
BAL1408	Scientific Laboratory Supplies	EACH	EUR 1324.8

PX323M Precision Balance. 320g (0.001g). InCal
BAL1322	Scientific Laboratory Supplies	EACH	EUR 1586.4

PX523M Precision Balance. 520g (0.001g). InCal
BAL1328	Scientific Laboratory Supplies	EACH	EUR 1413.6

PX3202 Precision Balance. 3200g (0.01g). InCal
BAL1332	Scientific Laboratory Supplies	EACH	EUR 1406.4

PX5202 Precision Balance. 5200g (0.01g). InCal
BAL1338	Scientific Laboratory Supplies	EACH	EUR 1254

Precision syringe 250ul with drain tube
WAT4840	Scientific Laboratory Supplies	EACH	EUR 655.41

PX3202M Precision Balance. 3200g (0.01g). InCal
BAL1334	Scientific Laboratory Supplies	EACH	EUR 1657.2

PX5202M Precision Balance. 5200g (0.01g). InCal
BAL1404	Scientific Laboratory Supplies	EACH	EUR 1453.5

AX223 220g 1mg Int Cal Precision Balance
BAL0015	Scientific Laboratory Supplies	EACH	EUR 2196

AX423 420g 1mg Int Cal Precision Balance
BAL0017	Scientific Laboratory Supplies	EACH	EUR 2420.4

AX523 520g 1mg Int Cal Precision Balance
BAL0019	Scientific Laboratory Supplies	EACH	EUR 2883.6

AX1502 1520g 0.01g Int Cal Precision Balance
BAL0023	Scientific Laboratory Supplies	EACH	EUR 2170.8

AX2202 2200g 0.01g Int Cal Precision Balance
BAL0025	Scientific Laboratory Supplies	EACH	EUR 2209.2

AX4202 4200g 0.01g Int Cal Precision Balance
BAL0027	Scientific Laboratory Supplies	EACH	EUR 2372.4

AX5202 5200g 0.01g Int Cal Precision Balance
BAL0029	Scientific Laboratory Supplies	EACH	EUR 2883.6

PX323/E Precision Balance. 320g (0.001g). ExCal
BAL1318	Scientific Laboratory Supplies	EACH	EUR 1056

PX523/E Precision Balance. 520g (0.001g). ExCal
BAL1324	Scientific Laboratory Supplies	EACH	EUR 1026

PX4201/E Precision Balance. 4200g (0.1g). ExCal
BAL1406	Scientific Laboratory Supplies	EACH	EUR 1078.8

PX3202/E Precision Balance. 3200g (0.01g). ExCal
BAL1330	Scientific Laboratory Supplies	EACH	EUR 1086

PX5202/E Precision Balance. 5200g (0.01g). ExCal
BAL1336	Scientific Laboratory Supplies	EACH	EUR 1054.5

2X PCR Precision™ MasterMix with dye
G124-dye	ABM	5.0 ml (200 Rxns)	EUR 195.6

Tweezer, Titanium, Micro Fine Tip Fine Precision, 115mm
43260013-1	Bio-WORLD	1 Each	EUR 94.4

Ohaus PR Series Precision Balances PR223 220g (0.001g)
BAL1490	Scientific Laboratory Supplies	EACH	EUR 1040.4

Ohaus PR Series Precision Balances PR423 420g (0.001g)
BAL1494	Scientific Laboratory Supplies	EACH	EUR 996

Ohaus PR Series Precision Balances PR523 520g (0.001g)
BAL1498	Scientific Laboratory Supplies	EACH	EUR 1117.2

Ohaus PR Series Precision Balances PR4201 4200g (0.1g)
BAL1574	Scientific Laboratory Supplies	EACH	EUR 996

Ohaus PR Series Precision Balances PR6201 6200g (0.1g)
BAL1578	Scientific Laboratory Supplies	EACH	EUR 1021.2

Ohaus PR Series Precision Balances PR1602 1600g (0.01g)
BAL1562	Scientific Laboratory Supplies	EACH	EUR 1066.8

Ohaus PR Series Precision Balances PR2202 2200g (0.01g)
BAL1566	Scientific Laboratory Supplies	EACH	EUR 1096.8

Ohaus PR Series Precision Balances PR4202 4200g (0.01g)
BAL1570	Scientific Laboratory Supplies	EACH	EUR 1068

SLS Lab Basics Compact Precision Balance 3100g x 0.1g
SLS5068	Scientific Laboratory Supplies	EACH	EUR 423.6

SLS Lab Pro P-Series Precision Balance 320g x 0.001g
SLS5062	Scientific Laboratory Supplies	EACH	EUR 1317.6

SLS Lab Pro P-Series Precision Balance 3200g x 0.01g
SLS5064	Scientific Laboratory Supplies	EACH	EUR 1317.6

Ohaus PR Series Precision Balances PR223/E 220g (0.001g)
BAL1488	Scientific Laboratory Supplies	EACH	EUR 854.4

Ohaus PR Series Precision Balances PR423/E 420g (0.001g)
BAL1492	Scientific Laboratory Supplies	EACH	EUR 873.6

Ohaus PR Series Precision Balances PR523/E 520g (0.001g)
BAL1496	Scientific Laboratory Supplies	EACH	EUR 919.2

Ohaus PR Series Precision Balances PR4201/E 4200g (0.1g)
BAL1572	Scientific Laboratory Supplies	EACH	EUR 796.8

Ohaus PR Series Precision Balances PR6201/E 6200g (0.1g)
BAL1576	Scientific Laboratory Supplies	EACH	EUR 835.2

SLS Lab Basics Compact Precision Balance 310g x 0.01g
SLS5066	Scientific Laboratory Supplies	EACH	EUR 362.4

Ohaus PR Series Precision Balances PR1602/E 1600g (0.01g)
BAL1548	Scientific Laboratory Supplies	EACH	EUR 873.6

Ohaus PR Series Precision Balances PR2202/E 2200g (0.01g)
BAL1564	Scientific Laboratory Supplies	EACH	EUR 891.6

Ohaus PR Series Precision Balances PR4202/E 4200g (0.01g)
BAL1568	Scientific Laboratory Supplies	EACH	EUR 882

Accuris™ Precision Balance, 120 grams, readability 0.001grams, 115V
W3200-120	Benchmark Scientific	1 each	EUR 1116.2

Accuris™ Precision Balance, 120 grams, readability 0.001grams, 230V
W3200-120-E	Benchmark Scientific	1 PC	EUR 1116.2

Accuris™ Precision Balance, 1200 grams, readability 0.01grams, 115V
W3200-1200	Benchmark Scientific	1 each	EUR 1121.9

Accuris™ Precision Balance, 1200 grams, readability 0.01grams, 230V
W3200-1200-E	Benchmark Scientific	1 PC	EUR 1121.9

Accuris™ Precision Balance, 320 grams, readability 0.001grams, 115V
W3200-320	Benchmark Scientific	1 each	EUR 1196.3

Accuris™ Precision Balance, 320 grams, readability 0.001grams, 230V
W3200-320-E	Benchmark Scientific	1 PC	EUR 1196.3

Accuris™ Precision Balance, 3200 grams, readability 0.01grams, 115V
W3200-3200	Benchmark Scientific	1 each	EUR 1196.3

Accuris™ Precision Balance, 3200 grams, readability 0.01grams, 230V
W3200-3200-E	Benchmark Scientific	1 PC	EUR 1196.3

Accuris™ Precision Balance, 500 grams, readability 0.001grams, 115V
W3200-500	Benchmark Scientific	1 each	EUR 1385.2

Accuris™ Precision Balance, 500 grams, readability 0.001grams, 230V
W3200-500-E	Benchmark Scientific	1 PC	EUR 1385.2

Accuris™ Precision Balance, 5000 grams, readability 0.01grams, 115V
W3200-5K	Benchmark Scientific	1 each	EUR 1648.5

Accuris™ Precision Balance, 5000 grams, readability 0.01grams, 230V
W3200-5K-E	Benchmark Scientific	1 PC	EUR 1648.5

Tweezers, Rubis Ultra Fine Straight Pointed Precision Tip, 120mm, 4.75€
25045-1	Polysciences Europe GmbH	1EA	EUR 49

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long
NMR1129	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long
NMR1130	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long
NMR1131	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long
NMR1132	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long
NMR1133	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 5 Long
NMR1134	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long
NMR1141	Scientific Laboratory Supplies	EACH	EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long
NMR1142	Scientific Laboratory Supplies	EACH	EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long
NMR1143	Scientific Laboratory Supplies	EACH	EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long
NMR1144	Scientific Laboratory Supplies	EACH	EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long
NMR1145	Scientific Laboratory Supplies	EACH	EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 7 Long
NMR1146	Scientific Laboratory Supplies	EACH	EUR 110.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long
NMR1153	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long
NMR1154	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long
NMR1155	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long
NMR1156	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long
NMR1157	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 200mhz 8 Long
NMR1158	Scientific Laboratory Supplies	EACH	EUR 111.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long
NMR1165	Scientific Laboratory Supplies	EACH	EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long
NMR1166	Scientific Laboratory Supplies	EACH	EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long
NMR1167	Scientific Laboratory Supplies	EACH	EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long
NMR1168	Scientific Laboratory Supplies	EACH	EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long
NMR1169	Scientific Laboratory Supplies	EACH	EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 5 Long
NMR1170	Scientific Laboratory Supplies	EACH	EUR 115.2

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long
NMR1177	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long
NMR1178	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long
NMR1179	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long
NMR1180	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long
NMR1181	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 7 Long
NMR1182	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long
NMR1189	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long
NMR1190	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long
NMR1191	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long
NMR1192	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long
NMR1193	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 300mhz 8 Long
NMR1194	Scientific Laboratory Supplies	EACH	EUR 114

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long
NMR1201	Scientific Laboratory Supplies	EACH	EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long
NMR1202	Scientific Laboratory Supplies	EACH	EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long
NMR1203	Scientific Laboratory Supplies	EACH	EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long
NMR1204	Scientific Laboratory Supplies	EACH	EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long
NMR1205	Scientific Laboratory Supplies	EACH	EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 5 Long
NMR1206	Scientific Laboratory Supplies	EACH	EUR 123.6

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 7 Long
NMR1213	Scientific Laboratory Supplies	EACH	EUR 122.4

J Young Wilmad Precision NMR Tube With 5mm NMR Valve 400mhz 7 Long
NMR1214	Scientific Laboratory Supplies	EACH	EUR 122.4