A Case for Using Genomics and a Bioinformatics Pipeline to Develop Sensitive and Species-Specific PCR-Based Diagnostics for Soil-Transmitted Helminths.
The steadiness of expense and ease of use vs. specificity and sensitivity in diagnostic assays for helminth illness is a crucial consideration, with expense and ease typically successful out in endemic areas the place funds and refined gear could also be scarce.
In this assessment, we argue that molecular diagnostics, particularly new assays which were developed with the help of next-generation sequence knowledge and strong bioinformatic instruments, greater than make up for their expense with the advantage of a clear and exact evaluation of the scenario on the bottom. Elimination efforts related to the London Declaration and the World Health Organization (WHO) 2020 Roadmap have resulted in areas of low illness incidence and diminished an infection burdens.
An correct evaluation of an infection ranges is vital for figuring out the place and when the applications could be efficiently ended. Thus, extra delicate assays are wanted in places the place elimination efforts are approaching a profitable conclusion. Although microscopy or extra basic PCR targets have a function to play, they will mislead and trigger research outcomes to be confounded. Hyper-specific qPCR assays allow a extra definitive evaluation of the scenario within the discipline, in addition to of shifting dynamics and rising illness
To choose, current, and summarize one of the best papers revealed in 2018 within the discipline of Knowledge Representation and Management (KRM).A complete and standardized assessment of the medical informatics literature was carried out to choose probably the most attention-grabbing papers revealed in 2018 in KRM, based mostly on PubMed and ISI Web Of Knowledge queries.Four finest papers have been chosen among the many 962 publications retrieved following the Yearbook assessment course of.
The analysis areas in 2018 have been primarily associated to the ontology-based knowledge integration for phenotype-genotype affiliation mining, the design of ontologies and their software, and the semantic annotation of medical texts.
A Case for Using Genomics and a Bioinformatics Pipeline to Develop Sensitive and Species-Specific PCR-Based Diagnostics for Soil-Transmitted Helminths
In the KRM choice for 2018, analysis on semantic representations demonstrated their added worth for enhanced deep studying approaches in textual content mining and for designing novel bioinformatics pipelines based mostly on graph databases. In addition, the ontology construction can enrich the analyses of complete genome expression knowledge. Finally, semantic representations demonstrated promising outcomes to course of phenotypic huge knowledge
Description: A polyclonal antibody against DDX11. Recognizes DDX11 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200
Description: A polyclonal antibody against DDX11. Recognizes DDX11 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Description: A polyclonal antibody against DDX11. Recognizes DDX11 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Rat Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Porcine Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Porcine Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Pig Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Porcine Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Rat Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Rat Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Rat Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Goat Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Goat Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
Description: A competitive ELISA for quantitative measurement of Goat Probable ATP dependent RNA helicase DDX11(DDX11) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Goat Probable ATP dependent RNA helicase DDX11(DDX11) ELISA kit
